I usually have just fruit for breakfast so do not take an Alli then, so take my multi-vitamin which is a gelcap, at that time. Lunch is around 3.00 p.m. and usually contains some fat so I take one Alli. By then I hope my multi-vitamin is already absorbed. Most days I take only one Alli, as lunch is my main meal. But if I go to dinner and expect to also have dessert, I take 2 Allis to absorb the extra fat.Does anyone know if this poses a problem? I never take more than 3 per day, but most days just one. If I forget to take one with a meal I just take it when I remember. My side effects are the same as everyone else's, just not in any embarrassing way. No cramping, no dripping. It is seriously expensive though......$1 per pill ($120 per bottle) which can last me 4 months if I take just one per day. I get at least 3 months from one bottle which makes it worth it to me. I really wasn't trying to lose weight at all but I did. I started taking Alli because I have a constipation problem and do not like taking laxatives. It has worked like a charm for me, but I have gone from 120 lbs. to 110 lbs. over a 6-month period. I do, however, feel much better than when I was lugging around an impacted colon. Maybe that accounted for the 10 lbs., and my stomach is as flat as a pancake.